製品の概要

  • 製品名Anti-HDAC1 antibody
    HDAC1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to HDAC1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-483 of Human HDAC1

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab55094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.
    • 組織特異性Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
    • 配列類似性Belongs to the histone deacetylase family. HD type 1 subfamily.
    • 翻訳後修飾Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
      Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
      Ubiquitinated by CHFR, leading to its degradation by the proteasome.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DKFZp686H12203 antibody
      • GON 10 antibody
      • HD1 antibody
      • HDAC 1 antibody
      • HDAC1 antibody
      • HDAC1_HUMAN antibody
      • Histone deacetylase 1 antibody
      • Reduced potassium dependency yeast homolog like 1 antibody
      • RPD3 antibody
      • RPD3L1 antibody
      see all

    Anti-HDAC1 antibody 画像

    • HDAC1 antibody (ab55094) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human liver.


    • Predicted band size : 55 kDa
      HDAC1 antibody (ab55094) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-HDAC1 antibody (ab55094) 使用論文

    ab55094 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab55094.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"