製品の概要

  • 製品名Anti-HCP1 antibody
    HCP1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to HCP1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    LKEPKSTRLFTFRH

    with a Cysteine residue linker, corresponding to internal sequence amino acids 233-247 of Human HCP1 (NP_542400.2).

  • ポジティブ・コントロール
    • Human liver lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).

ターゲット情報

  • 機能Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
  • 組織特異性Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.
  • 関連疾患Defects in SLC46A1 are the cause of hereditary folate malabsorption (HFM) [MIM:229050]. HFM is a rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent.
  • 配列類似性Belongs to the major facilitator superfamily. SLC46A family.
  • 細胞内局在Apical cell membrane. Cytoplasm. Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • G21 antibody
    • HCP 1 antibody
    • Heme carrier protein 1 antibody
    • MGC9564 antibody
    • PCFT antibody
    • PCFT/HCP1 antibody
    • PCFT_HUMAN antibody
    • PDE7A antibody
    • Proton coupled folate transporter antibody
    • Proton-coupled folate transporter antibody
    • SLC46A1 antibody
    • Solute carrier family 46 (folate transporter) member 1 antibody
    • Solute carrier family 46 member 1 antibody
    see all

Anti-HCP1 antibody 画像

  • Anti-HCP1 antibody (ab118384) at 0.3 µg/ml (for 1 hour) + Human Liver lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 50 kDa

Anti-HCP1 antibody (ab118384) 使用論文

ab118384 has not yet been referenced specifically in any publications.

Product Wall

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this h...

Read More

Thank you for your reply with further information.

Reviewing the protocol and testing conditions, I do not think that further optimization will improve the results signficantly. You may of received a faulty vial or batch, and I must apologiz...

Read More

I am sorry to hear you have been experiencing problems with ab11834.

As we discussed over the phone, please could you send an image of your results and a bit more information about the protocol. Here are some further questions:

- ...

Read More

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"