Anti-Hck 抗体 [EP2415Y] (ab75839)

製品の概要

• 製品名
  Anti-Hck antibody [EP2415Y]
  Hck 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EP2415Y] to Hck
• 特異性
  This protein is known to be similar in amino acid sequence to LCK (P06239), FYN (P06241), YES1 (P07947), SRC (P12931), and LYN (P07948). Therefore, cross-reactivity with these homologous proteins may be observed. We would be happy to provide immunogen alignment information upon request, please contact our Scientific Support for further information.
• アプリケーション
  適用あり: WB, IP, ICC, Flow Cytmore details
  適用なし: IHC-P
• 種交差性
  交差種: Human
  
• 免疫原

  A synthetic peptide corresponding to residues near the C terminus of human Hck

• ポジティブ･コントロール
  • TF-1 cell lysate.
• 特記事項

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EP2415Y
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Src Family

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling

アプリケーション

ターゲット情報

• 機能
  May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
• 組織特異性
  Expressed predominantly in cells of the myeloid and B-lymphoid lineages.
• 配列類似性
  Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
  Contains 1 protein kinase domain.
  Contains 1 SH2 domain.
  Contains 1 SH3 domain.
• ドメイン
  The SH3 domain mediates binding to HIV-1 Nef.
• 細胞内局在
  Membrane. Cytoplasm. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated and Membrane. Membrane > caveola. 20% of this isoform is associated with caveolae, this association depends on palmitoylation of cyteine at position 3.

• Target information above from: UniProt accession P08631 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 3055 Human
  • Omim: 142370 Human
  • SwissProt: P08631 Human
  • Unigene: 655210 Human
• 製品の状態
  This protein is known to be similar in amino acid sequence to LCK (P06239), FYN (P06241), YES1 (P07947), SRC (P12931), and LYN (P07948). Therefore, cross-reactivity with these homologous proteins may be observed. We would be happy to provide immunogen alignment information upon request.
• 別名
  • Bmk antibody
  • Hck 1 antibody
  • Hck antibody

  • HCK_HUMAN antibody
  • Hemopoietic cell kinase antibody
  • JTK9 antibody
  • p59-HCK/p60-HCK antibody
  • p59Hck antibody
  • p59HCK/p60HCK antibody
  • p61Hck antibody
  • Tyrosine protein kinase HCK antibody
  • Tyrosine-protein kinase HCK antibody

  see all

プロトコール

• Flow cytometry protocols
• Immunoprecipitation protocols
• Immunocytochemistry & immunofluorescence protocols
• Western blot protocols