This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

製品の概要

  • 製品名Anti-hCG receptor antibody
    hCG receptor 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to hCG receptor

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 種交差性

    交差が予測される動物種: Human, Cynomolgus Monkey, Marmoset (common)
  • 免疫原

    Synthetic peptide:

    CQGTALLDKTRYTE

    , corresponding to C terminal amino acids 685-698 of Human hCG receptor according to NP_000224.2.

  • ポジティブ・コントロール
    • Lysates of Human Brain, Placenta and Prostate and of cell lines Daudi, HeLa and K562.

製品の特性

アプリケーション

  • 追加情報This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:32,000.
    Western Blot: Preliminary experiments gave an approx 35kDa band in lysates of Human Brain, Placenta and Prostate and of cell lines Daudi, HeLa and K562 after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 78.6kDa according to NP_000224.2. The 35kDa band was successfully blocked by incubation with the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
    • 組織特異性Gonadal and thyroid cells.
    • 関連疾患Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.
      Defects in LHCGR are the cause of luteinizing hormone resistance (LHR) [MIM:238320]; also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
    • 配列類似性Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
      Contains 6 LRR (leucine-rich) repeats.
      Contains 1 LRRNT domain.
    • 細胞内局在Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Gonadotropin receptor antibody
      • Gpcr19-rs1 antibody
      • GTHR-II antibody
      • HHG antibody
      • LCGR antibody
      • LGR2 antibody
      • LH-R antibody
      • LH/CG R antibody
      • LH/CG-R antibody
      • LH/CGR antibody
      • LHCGR antibody
      • LHR antibody
      • LHRHR antibody
      • LSH R antibody
      • LSH-R antibody
      • LSHR_HUMAN antibody
      • Luteinizing hormone receptor antibody
      • Luteinizing hormone/choriogonadotropin receptor antibody
      • Lutropin choriogonadotropic hormone receptor antibody
      • Lutropin choriogonadotropic receptor antibody
      • Lutropin-choriogonadotropic hormone receptor antibody
      • ULG5 antibody
      see all

    Anti-hCG receptor antibody (ab59019) 使用論文

    ab59019 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"