Anti-HBEGF/DTR 抗体 [MM0324-3R44] (ab89241)
Key features and details
- Mouse monoclonal [MM0324-3R44] to HBEGF/DTR
- Suitable for: Neutralising, WB
- Reacts with: Human
- Isotype: IgG2
製品の概要
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製品名
Anti-HBEGF/DTR antibody [MM0324-3R44]
HBEGF/DTR 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MM0324-3R44] to HBEGF/DTR -
由来種
Mouse -
アプリケーション
適用あり: Neutralising, WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human HBEGF/DTR.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. -
ポリ/モノ
モノクローナル -
クローン名
MM0324-3R44 -
アイソタイプ
IgG2 -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab89241の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Neutralising |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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特記事項 |
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Neutralising
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. -
配列類似性
Contains 1 EGF-like domain. -
翻訳後修飾
Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937). -
細胞内局在
Cell membrane and Secreted > extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor. - Information by UniProt
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参照データベース
- Entrez Gene: 1839 Human
- Omim: 126150 Human
- SwissProt: Q99075 Human
- Unigene: 799 Human
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別名
- diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody
- diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody
- Diphtheria toxin receptor antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (2)
ab89241 は 2 報の論文で使用されています。
- Luo P et al. s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide. Cell Res 30:779-793 (2020). PubMed: 32296111
- Liu J et al. CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17. Int J Biol Sci 15:493-506 (2019). PubMed: 30745837