製品の概要

  • 製品名Harmine
  • 製品の詳細
    Potent and selective inhibitor of DYRK1A
  • 生理活性の詳細Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
  • 精製度> 98%

製品の特性

  • 体系名7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
  • 分子量212.25
  • 構造式Chemical Structure
  • 分子式C13H12N2O
  • CAS 番号442-51-3
  • PubChem 登録番号5280953
  • 保存方法Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記COc1ccc3c(c1)nc2c3ccnc2C
  • 由来

    Synthetic

  • 研究分野

    Harmine (ab120225) 使用論文

    This product has been referenced in:
    • Waki H  et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5:357-70 (2007). Read more (PubMed: 17488638) »
    • Bain J  et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007). Read more (PubMed: 17850214) »
    • Song Y  et al. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem Biophys Res Commun 317:128-32 (2004). Read more (PubMed: 15047157) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"