Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.