Anti-H1N1 Influenza A virus Nucleocapsid protein 抗体 (ab104870)
Key features and details
- Rabbit polyclonal to H1N1 Influenza A virus Nucleocapsid protein
- Suitable for: WB, ELISA, ICC/IF
- Reacts with: Influenza A
- Isotype: IgG
製品の概要
-
製品名
Anti-H1N1 Influenza A virus Nucleocapsid protein antibody -
製品の詳細
Rabbit polyclonal to H1N1 Influenza A virus Nucleocapsid protein -
由来種
Rabbit -
アプリケーション
適用あり: WB, ELISA, ICC/IFmore details -
種交差性
交差種: Influenza A -
免疫原
Synthetic peptide derived from internal part of H1N1 Influenza A virus Nucleocapsid protein.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
Constituent: Whole serum -
Concentration information loading...
-
精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab104870の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
Use at an assay dependent concentration. Predicted molecular weight: 56 kDa.
Dilute 1:200 - 1:2000 |
|
ELISA |
Use at an assay dependent concentration.
|
|
ICC/IF |
Use at an assay dependent concentration.
|
特記事項 |
---|
WB
Use at an assay dependent concentration. Predicted molecular weight: 56 kDa. Dilute 1:200 - 1:2000 |
ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
-
関連性
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus. -
細胞内局在
Virion. Host nucleus -
参照データベース
- SwissProt: P03466 Influenza A
-
別名
- NP antibody
- Nucleocapsid protein antibody
- Nucleoprotein antibody
- Protein N antibody
プロトコール
データシートおよび資料
-
Datasheet download
参考文献 (6)
ab104870 は 6 報の論文で使用されています。
- Liu Y et al. ILDR1 promotes influenza A virus replication through binding to PLSCR1. Sci Rep 12:8515 (2022). PubMed: 35595813
- Ren L et al. Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral Replication. Virol Sin 36:1532-1542 (2021). PubMed: 34519916
- Yuan S et al. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv 6:eaba7910 (2020). PubMed: 32923629
- Menikou S et al. A proteomics-based method for identifying antigens within immune complexes. PLoS One 15:e0244157 (2020). PubMed: 33362259
- Ren L et al. Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1a via inhibition of proteasome. Virology 530:51-58 (2019). PubMed: 30780125
- Švancarová P & Betáková T Conserved methionine 165 of matrix protein contributes to the nuclear import and is essential for influenza A virus replication. Virol J 15:187 (2018). PubMed: 30509291