製品の概要

  • 製品名
    GYKI 53655 hydrochloride
  • 製品の詳細
    Non-competitive AMPA / kainate receptor antagonist
  • 別名
    • LY300168
  • 生理活性の詳細
    Non-competitive AMPA and kainate receptor antagonist. (IC50 values for inhibition of AMPA-mediated responses in cells expressing human GluR1 and GluR4 are 6 and 5 µM, respectively). Analog of GYKI 52466 (ab120336). Anticonvulsant in vivo. At higher concentrations blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM).

    Also available in simple stock solutions (ab144499) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度
    > 99%

製品の特性

関連製品

参考文献

This product has been referenced in:
  • Szabados T  et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull 55:387-91 (2001). Read more (PubMed: 11489346) »
  • Partin KM & Mayer ML Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655. Mol Pharmacol 49:142-8 (1996). Read more (PubMed: 8569699) »
  • Bleakman D  et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology 35:1689-702 (1996). Read more (PubMed: 9076748) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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