製品の概要

  • 製品名
    GW791343
  • 製品の詳細
    P2X7 allosteric modulator
  • 生理活性の詳細
    P2X7 allosteric modulator. Activity differs with species: acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7 receptors that increases the potency and effect of ATP.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Michel AD  et al. Mechanism of action of species-selective P2X(7) receptor antagonists. Br J Pharmacol 156:1312-25 (2009). Read more (PubMed: 19309360) »
  • Michel AD  et al. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol 153:737-50 (2008). Read more (PubMed: 18071294) »
  • Michel AD  et al. Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects. Br J Pharmacol 155:738-51 (2008). Read more (PubMed: 18660826) »

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