製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Guinea pig
    • 配列
      QEDPNAYSEEFFDV
    • 領域
      232 to 245

特性

Our Abpromise guarantee covers the use of ab38200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • 再構成
    Reconstitute with deionized water. (A stock solution of 2mgs/ml is recommended for most absorption control applications.)

関連情報

  • 別名
    • ADCA
    • Alpha neoendorphin
    • Beta neoendorphin
    • Beta-neoendorphin-dynorphin
    • Big Dyn
    • Big dynorphin
    • Dyn
    • Dyn-A17
    • Dyn-B
    • Dynorphin A
    • Dynorphin A(1-13)
    • Dynorphin A(1-17)
    • Dynorphin A(1-8)
    • Dynorphin B
    • Dynorphin B(1-13)
    • Dynorphin B-29
    • Enkephalin B
    • Leu enkephalin
    • Leumorphin
    • Neoendorphin dynorphin enkephalin prepropeptide
    • PDYN
    • PDYN_HUMAN
    • PENKB
    • Preprodynorphin
    • Preproenkephalin B
    • Prodynorphin
    • Proenkephalin B
    • Rimorphin
    • SCA23
    see all
  • 機能
    Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • 関連疾患
    Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • 配列類似性
    Belongs to the opioid neuropeptide precursor family.
  • 翻訳後修飾
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 細胞内局在
    Secreted.
  • Information by UniProt

参考文献

ab38200 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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