GSK3 beta (phospho Y216) peptide (ab110532)

製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列

    関連製品

    特性

    Our Abpromise guarantee covers the use of ab110532 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Blocking - Blocking peptide for Anti-GSK3 beta (phospho Y216) antibody (ab75745)

    • 製品の状態Liquid
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped at 4°C. Store at -20ºC.

      Constituents: PBS, EDTA, 1% BSA, 5% DMF, 5% Glycerol

    関連情報

    • 別名
      • Glycogen Synthase Kinase 3 Beta
      • Glycogen synthase kinase-3 beta
      • GSK 3 beta
      • GSK-3 beta
      • GSK3B
      • GSK3B_HUMAN
      • GSK3beta isoform
      • Serine/threonine-protein kinase GSK3B
      see all
    • 機能Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
    • 組織特異性Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
    • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
      Contains 1 protein kinase domain.
    • 翻訳後修飾Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216.
    • 細胞内局在Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
    • Information by UniProt

    GSK3 beta (phospho Y216) peptide (ab110532) 使用論文

    ab110532 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry.

    We sell this product in Liquid format and each vial contains 100 µg product (at a concentration of 1mg/ml).

    I hope this helps and if I can assist further, please do not hesitate to contact me.

    Thank you for your enquiry.

    The molecular weight of this peptide is around 1630 Da. We only provide one size of this product that is 100 ul (1 mg/ml).

    I hope this helps and if I can assist further, please do not hesitate to contact me.

    Thank you for your new enquiry regarding ab110532.

    I regret to inform you that we are unable to change the storage buffer for this particular product. Apologies!

    If you need any further assistance in the future, please do not hesita...

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    Thank you for your enquiry and your interest.

    The exact peptide sequence is commercially sensitive information and we can't release it. I can confirm that the peptide was synthesized and at position Y216 the Tyr is phosphorylated.

    I...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"