製品の概要

  • 製品名Anti-GSK3 beta antibody
    GSK3 beta 一次抗体 製品一覧
  • 製品の詳細
    Sheep polyclonal to GSK3 beta
  • アプリケーション適用あり: IPmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide:

    CNAASASASNST

    , corresponding to C terminal amino acids 410-420 of Human GSK3 beta conjugated to KLH

  • ポジティブ・コントロール
    • Rat liver lysate.

アプリケーション

Our Abpromise guarantee covers the use of ab65740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 10 µg/mg of lysate.

ターゲット情報

  • 機能Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
  • 組織特異性Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216.
  • 細胞内局在Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Glycogen Synthase Kinase 3 Beta antibody
    • Glycogen synthase kinase-3 beta antibody
    • GSK 3 beta antibody
    • GSK-3 beta antibody
    • GSK3B antibody
    • GSK3B_HUMAN antibody
    • GSK3beta isoform antibody
    • Serine/threonine-protein kinase GSK3B antibody
    see all

Anti-GSK3 beta antibody 画像

  • Immunoprecipitation of ab65740 with rat liver lysate using protein G beads (lane 1), and controls using beads alone (lane 2). Western blot analysis by another commercially available GSK3 antibody. Predicted Molecular weight 47kDa.

Anti-GSK3 beta antibody (ab65740) 使用論文

ab65740 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"