Selective ERRβ/γ agonist. Displays selectivity for ERRβ/γ over ERRα/β as well as other classical estrogen receptors. ERRβ is transiently induced and ERRγ is dramatically induced in vitro. Cell-permeable. Increases glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 mRNA in vitro.
Store at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wang SC et al. An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol Cell Endocrinol315:146-52 (2010).
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Kim Y et al. Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach. J Comb Chem11:928-37 (0).
Read more (PubMed: 19746993) »