製品の概要

  • 製品名
    GSK 4716
  • 製品の詳細
    Selective ERRβγ agonist
  • 生理活性の詳細
    Selective ERRβ/γ agonist. Displays selectivity for ERRβ/γ over ERRα/β as well as other classical estrogen receptors. ERRβ is transiently induced and ERRγ is dramatically induced in vitro. Cell-permeable. Increases glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 mRNA in vitro.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Wang SC  et al. An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol Cell Endocrinol 315:146-52 (2010). Read more (PubMed: 19631715) »
  • Kim Y  et al. Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach. J Comb Chem 11:928-37 (0). Read more (PubMed: 19746993) »

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