製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to GSDMB
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment corresponding to Human GSDMB aa 21-194.

  • ポジティブ・コントロール
    • HeLa whole cell lysate.

法規制情報

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab103980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.

ターゲット情報

  • 機能
    The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown.
  • 組織特異性
    In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
  • 配列類似性
    Belongs to the gasdermin family.
  • ドメイン
    Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
  • 細胞内局在
    Cytoplasm. Cytoplasm, cytosol. Cell membrane. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
  • Information by UniProt
  • 参照データベース
  • 製品の状態
    There are 5 isoforms produced by alternative splicing.
  • 別名
    • 123 antibody
    • 156 antibody
    • Gasdermin B antibody
    • Gasdermin like protein antibody
    • Gasdermin-B antibody
    • Gasdermin-like protein antibody
    • GSDMB antibody
    • GSDMB_HUMAN antibody
    • GSDML antibody
    • PP4052 antibody
    • PRO2521 antibody
    see all

画像

  • Anti-GSDMB antibody (ab103980) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 47 kDa
    10% SDS-PAGE.

プロトコール

参考文献

ab103980 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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