製品の概要

  • 製品名Anti-GRXCR1 antibody
    GRXCR1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GRXCR1
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: GVKYKVSAGQ ALFNNLTKVL QQPSTDLEFD RVVIYTTCLR VVRTTFERCE LVRKIFQNHR VKFEEKNIAL NGEYGK, corresponding to amino acids 108-183 of Human GRXCR1.

  • ポジティブ・コントロール
    • Human nasopharynx tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab122670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

ターゲット情報

  • 機能May play a role in actin filament architecture in developing stereocilia of sensory cells.
  • 組織特異性Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.
  • 関連疾患Defects in GRXCR1 are the cause of deafness autosomal recessive type 25 (DFNB25) [MIM:613285]. DFNB25 is characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals and vestibular dysfunction is observed in some affected individuals.
  • 配列類似性Belongs to the GRXCR1 family.
    Contains 1 glutaredoxin domain.
  • 細胞内局在Cell projection > stereocilium. Cell projection > microvillus. Cell projection > kinocilium. In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DFNB25 antibody
    • Glutaredoxin domain-containing cysteine-rich protein 1 antibody
    • Glutaredoxin, cysteine rich 1 antibody
    • GRCR1_HUMAN antibody
    • Grxcr1 antibody
    see all

Anti-GRXCR1 antibody 画像

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli and cell junctions. Recommended concentration of ab122670 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122670, at 1/50 dilution, staining GRXCR1 in paraffin-embedded Human nasopharynx tissue by Immunohistochemistry.

Anti-GRXCR1 antibody (ab122670) 使用論文

ab122670 has not yet been referenced specifically in any publications.

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