製品の概要

  • 製品名
    Anti-GRK6 antibody - Carboxyterminal end
    GRK6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GRK6 - Carboxyterminal end
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected within aa 500~600 of human GRK6.

  • ポジティブ･コントロール
    • HeLa cell lysate, Mouse heart tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab38291 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能
    Specifically phosphorylates the activated forms of G protein-coupled receptors.
  • 組織特異性
    Widely expressed.
  • 配列類似性
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • 翻訳後修飾
    It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
    • 製品の状態
      There are 2 isoforms produced by alternative splicing.
    • 別名
      • FLJ32135 antibody
      • G protein coupled receptor kinase 6 antibody
      • G protein coupled receptor kinase GRK6 antibody
      • G protein-coupled receptor kinase 6 antibody
      • G protein-coupled receptor kinase GRK6 antibody
      • Gprk6 antibody
      • Grk6 antibody
      • GRK6_HUMAN antibody
      see all

    画像

    • Western blot - Anti-GRK6 antibody - Carboxyterminal end (ab38291)
      Western blot - Anti-GRK6 antibody - Carboxyterminal end (ab38291)
      All lanes : Anti-GRK6 antibody - Carboxyterminal end (ab38291) at 1/100 dilution

      Lane 1 : HeLa cell lysate.
      Lane 2 : Mouse heart tissue lysate.

      Secondary
      All lanes : HRP-anti-rabbit.

      Developed using the ECL technique.

      Predicted band size: 66 kDa
      Observed band size: 66 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRK6 antibody - Carboxyterminal end (ab38291)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRK6 antibody - Carboxyterminal end (ab38291)
      ab38291 (1/50) staining human cancer tissue by immunohistochemistry, formalin-fixed, paraffin-embedded tissue. The breast carcinoma tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    参考文献

    This product has been referenced in:
    • Tiedemann RE  et al. Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. Blood 115:1594-604 (2010). WB ; Human . Read more (PubMed: 19996089) »

    See 1 Publication for this product

    ab38291 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

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