製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to GRK2
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Hamster, Cow, Dog, Chimpanzee, Macaque monkey
  • 免疫原

    Synthetic peptide:

    C-RDAYREAQQLVQR

    , corresponding to internal sequence amino acids 648-660 of Human GRK2.

  • ポジティブ・コントロール
    • Human lysates of Burkitt's lymphoma cell line Daudi

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab47999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報
    ELISA: detection limit dilution 1/16000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 80 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
    • 組織特異性
      Expressed in peripheral blood leukocytes.
    • 配列類似性
      Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 PH domain.
      Contains 1 protein kinase domain.
      Contains 1 RGS domain.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ADRBK1 antibody
      • Adrenergic beta receptor kinase 1 antibody
      • ARBK1_HUMAN antibody
      • BARK antibody
      • BARK1 antibody
      • Beta adrenergic receptor kinase 1 antibody
      • Beta ARK 1 antibody
      • Beta ARK1 antibody
      • Beta-adrenergic receptor kinase 1 antibody
      • Beta-ARK-1 antibody
      • FLJ16718 antibody
      • G protein coupled receptor kinase 2 antibody
      • G-protein coupled receptor kinase 2 antibody
      • GRK2 antibody
      see all

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    プロトコール

    参考文献

    ab47999 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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