製品の概要

  • 製品名Anti-GRIM19 antibody
    GRIM19 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to GRIM19
  • アプリケーション適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human GRIM19 (AAH09189.1).

  • ポジティブ・コントロール
    • Human liver lysate, GRIM19 transfected 293T cell lysate, HeLa cells and Human pancreas.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab88094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
ICC/IF
  • 追加情報ICC/IF: Use at a concentration of 10 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml. Perform heat mediated antigen retrieval via the microwave method in 1X citrate buffer (pH 6.0) before commencing with IHC staining protocol.
    WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
    • 組織特異性Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
    • 関連疾患Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
    • 配列類似性Belongs to the complex I NDUFA13 subunit family.
    • 発生段階Expressed in numerous fetal tissues.
    • 細胞内局在Mitochondrion inner membrane. Nucleus. May be translocated into the nucleus upon IFN/RA treatment.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 2700054G14Rik antibody
      • AU022060 antibody
      • B16.6 antibody
      • CDA016 antibody
      • Cell death regulatory protein antibody
      • Cell death regulatory protein GRIM-19 antibody
      • CGI-39 antibody
      • CGI39 protein antibody
      • CI-B16.6 antibody
      • Complex I-B16.6 antibody
      • FLJ58045 antibody
      • FLJ59191 antibody
      • Gene associated with retinoic and IFN-induced mortality 19 protein antibody
      • Gene associated with retinoic and interferon-induced mortality 19 protein antibody
      • Gene associated with retinoic interferon induced mortality 19 protein antibody
      • GRIM-19 antibody
      • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody
      • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 antibody
      • NADH ubiquinone oxidoreductase B16.6 subunit antibody
      • NADH-ubiquinone oxidoreductase B16.6 subunit antibody
      • NDUAD_HUMAN antibody
      • NDUFA13 antibody
      • RGD1565358 antibody
      see all

    Anti-GRIM19 antibody 画像

    • Anti-GRIM19 antibody (ab88094) at 1 µg/ml + human liver lysate at 50 µg

      Predicted band size : 17 kDa
      Observed band size : 19 kDa (why is the actual band size different from the predicted?)
    • All lanes : Anti-GRIM19 antibody (ab88094) at 1 µg/ml

      Lane 1 : GRIM19 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.


      Predicted band size : 17 kDa
      Observed band size : 14 kDa (why is the actual band size different from the predicted?)
    • ab88094, at 3 µg/ml, staining GRIM19 in formalin-fixed, paraffin-embedded human pancreas by Immunohistochemistry.
    • ab88094, at 10 µg/ml staining GRIM19, in HeLa cells by Immunofluorescence.

    Anti-GRIM19 antibody (ab88094) 使用論文

    ab88094 has not yet been referenced specifically in any publications.

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