製品の概要

  • 製品名Anti-GRIM19 antibody
    GRIM19 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GRIM19
  • 特異性Reacts with the human GRIM-19 protein.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 特記事項


    Antisense expression of GRIM 19 (Genes associated with Retinoid-IFN-induced Mortality) confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM 19 protein. Overexpression of GRIM 19 enhances cell death in response to IFN/RA. GRIM 19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM 19 is a novel cell death-regulatory molecule.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab3449 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 16 kDa (predicted molecular weight: 16 kDa).

ターゲット情報

  • 機能Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
  • 組織特異性Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
  • 関連疾患Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
  • 配列類似性Belongs to the complex I NDUFA13 subunit family.
  • 発生段階Expressed in numerous fetal tissues.
  • 細胞内局在Mitochondrion inner membrane. Nucleus. May be translocated into the nucleus upon IFN/RA treatment.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2700054G14Rik antibody
    • AU022060 antibody
    • B16.6 antibody
    • CDA016 antibody
    • Cell death regulatory protein antibody
    • Cell death regulatory protein GRIM-19 antibody
    • CGI-39 antibody
    • CGI39 protein antibody
    • CI-B16.6 antibody
    • Complex I-B16.6 antibody
    • FLJ58045 antibody
    • FLJ59191 antibody
    • Gene associated with retinoic and IFN-induced mortality 19 protein antibody
    • Gene associated with retinoic and interferon-induced mortality 19 protein antibody
    • Gene associated with retinoic interferon induced mortality 19 protein antibody
    • GRIM-19 antibody
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody
    • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 antibody
    • NADH ubiquinone oxidoreductase B16.6 subunit antibody
    • NADH-ubiquinone oxidoreductase B16.6 subunit antibody
    • NDUAD_HUMAN antibody
    • NDUFA13 antibody
    • RGD1565358 antibody
    see all

Anti-GRIM19 antibody (ab3449) 使用論文

ab3449 has not yet been referenced specifically in any publications.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"