製品の概要

  • 製品名Anti-GRIK2 antibody
    GRIK2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GRIK2
  • 特異性ab28697 recognises Glutamate receptor, ionotropic kainate 2 precursor (GRIK2).
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide derived from a region between 156-205 of human GRIK2. (Note: the exact amino acid sequence is proprietary).

  • ポジティブ・コントロール
    • Jurkat Cell Lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab28697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 103 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/62500.

ターゲット情報

  • 機能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.
  • 組織特異性Expression is higher in cerebellum than in cerebral cortex.
  • 関連疾患Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal.
  • 配列類似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily.
  • 翻訳後修飾Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1.
    Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome.
  • 細胞内局在Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bA487F5.1 antibody
    • EAA4 antibody
    • Excitatory amino acid receptor 4 antibody
    • GLR 6 antibody
    • GLR6 antibody
    • GluK2 antibody
    • GLUK6 antibody
    • GLUR 6 antibody
    • GluR-6 antibody
    • GluR6 antibody
    • Glutamate receptor 6 antibody
    • Glutamate receptor antibody
    • glutamate receptor form A antibody
    • glutamate receptor form B antibody
    • glutamate receptor form C antibody
    • glutamate receptor form D antibody
    • glutamate receptor form E antibody
    • Glutamate receptor ionotropic kainate 2 antibody
    • GRIK 2 antibody
    • GRIK2 antibody
    • GRIK2 protein antibody
    • GRIK2_HUMAN antibody
    • ionotropic kainate 2 antibody
    • MRT6 antibody
    see all

Anti-GRIK2 antibody 画像

Anti-GRIK2 antibody (ab28697) 使用論文

ab28697 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"