The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000. Predicted molecular weight: 36 kDa.
1/100. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
機能Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
組織特異性Ubiquitous. Most abundantly expressed in the liver.
関連疾患Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
配列類似性Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
HEK293T cells transfected with either RC200963 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by ab119081 at a dilution of 1/100, and then analyzed by flow cytometry.
Anti-GRHPR antibody [OTI9G2] (ab119081) 使用論文
has not yet been referenced specifically in any publications.