The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
機能Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
組織特異性Highly and constitutively expressed in activated natural killer (NK) cells.
配列類似性Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain.
細胞内局在Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.