製品の概要

  • 製品名Anti-Granulin antibody
    Granulin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Granulin
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from the C-terminal region of human Granulin.

  • ポジティブ・コントロール
    • Human MDA-MB-231 breast adenocarcinoma, PC-3 prostate adenocarcinoma (bone metastatic site), HeLa cervical carcinoma, and HT1080 fibrosarcoma lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報IP: Use at a concentration of 7 µg/reaction.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects bands varying from approximately 64-88 kDa depending on degree of protein glycosylation.(predicted molecular weight: 64 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
      Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
    • 組織特異性In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
    • 関連疾患Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
    • 配列類似性Belongs to the granulin family.
    • 翻訳後修飾Granulins are disulfide bridged.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Acrogranin antibody
      • CLN11 antibody
      • GEP antibody
      • GP88 antibody
      • Granulin A antibody
      • Granulin B antibody
      • Granulin C antibody
      • Granulin D antibody
      • Granulin E antibody
      • Granulin epithelin antibody
      • Granulin F antibody
      • Granulin G antibody
      • Granulin-7 antibody
      • Granulins antibody
      • GRN antibody
      • GRN_HUMAN antibody
      • PC cell derived growth factor antibody
      • PCDGF antibody
      • PEPI antibody
      • PGRN antibody
      • Proepithelin antibody
      • Progranulin antibody
      see all

    Anti-Granulin antibody 画像

    • All lanes : Anti-Granulin antibody (ab53880) at 1 µg/ml

      Lane 1 : MDA-MB-231 cell lysate
      Lane 2 : PC-3 cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : HT1080 cell lysate


      Predicted band size : 64 kDa
      Observed band size : 64 kDa

    Anti-Granulin antibody (ab53880) 使用論文

    ab53880 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. I contacted the originator of ab53880 Granulin antibody who have kindly provided the following information. A BLAST search with the immunogen used for the antibody and the protein accession P28799 and below show 100%...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"