製品の概要

  • 製品名
    GR113808
  • 製品の詳細
    Potent, highly selective 5-HT4 antagonist
  • 生理活性の詳細
    Potent, highly selective 5-HT4 receptor antagonist (pKb = 8.8). Displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. Decreases water intake and potentiates drinking.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Castro L  et al. Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia. Braz J Med Biol Res 34:791-6 (2001). Read more (PubMed: 11378670) »
  • Gale JD  et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. Br J Pharmacol 111:332-8 (1994). Read more (PubMed: 8012715) »
  • Kaumann AJ Blockade of human atrial 5-HT4 receptors by GR 113808. Br J Pharmacol 110:1172-4 (1993). Read more (PubMed: 8298805) »

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