GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist (ab120523)
Key features and details
- Potent, selective 5-HT1B/1D receptor antagonist
- CAS Number: 148642-42-6
- Purity: > 97%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist -
製品の詳細
Potent, selective 5-HT1B/1D receptor antagonist -
生理活性の詳細
Potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both 5-HT1D in rat and 5-HT1D in guinea pig). 100-fold selectivity over 5-HT1A, 5-HT1E, and 5-HT2C. Displays centrally mediated effects upon systemic administration.
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精製度
> 97% -
CAS 番号
148642-42-6 -
構造式
製品の特性
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体系名
N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride -
分子量
534.06 -
分子式
C29H31N5O3.HCl -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab120523 は 2 報の論文で使用されています。
- Burke DA & Alvarez VA Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell Rep 39:110795 (2022). PubMed: 35545050
- Asaoka N et al. Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAB receptor-mediated inhibition of L-type calcium channels. Sci Rep 7:13609 (2017). PubMed: 29051549