製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to GPSM2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog
  • 免疫原

    Synthetic peptide:

    C-NRLKGKKYKTNSSTK

    , corresponding to internal sequence amino acids 441-455 of Human GPSM2

  • ポジティブ・コントロール
    • Human Brain (Cerebellum) lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 76 kDa). An additional band observed at 26-28kDa can be blocked by incubation with the immunising peptide.

ターゲット情報

  • 機能
    Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
  • 組織特異性
    Ubiquitously expressed.
  • 関連疾患
    Defects in GPSM2 are the cause of deafness autosomal recessive type 82 (DFNB82) [MIM:613557]. DFNB82 is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss. There are no symptoms of vestibular dysfunction.
  • 配列類似性
    Belongs to the GPSM family.
    Contains 4 GoLoco domains.
    Contains 8 TPR repeats.
  • 細胞内局在
    Cytoplasm. Cytoplasm > cell cortex. Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DFNB82 antibody
    • G protein signalling modulator 2 (AGS3 like C. elegans) antibody
    • G protein signalling modulator 2 antibody
    • G-protein-signaling modulator 2 antibody
    • Gpsm2 antibody
    • GPSM2_HUMAN antibody
    • HGNC:29501 antibody
    • LGN antibody
    • LGN protein antibody
    • Mosaic protein LGN antibody
    • Pins antibody
    see all

画像

  • Anti-GPSM2 antibody (ab59128) at 0.01 µg/ml + Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer)

    Predicted band size : 76 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 27 kDa. We are unsure as to the identity of these extra bands.

プロトコール

参考文献

ab59128 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab59128.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録