Anti-GPSM1 抗体 (ab111022)

製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to GPSM1
  • アプリケーション
    適用あり: IHC-Fr, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, a wide range of other species
  • 免疫原

    Synthetic peptide, derived from an internal region of Human GPSM1 (UniProt ID: Q86YR5).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration.
WB 1/1000 - 1/5000. Predicted molecular weight: 75 kDa.
IHC-P 1/100 - 1/1000.

ターゲット情報

  • 機能
    Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
  • 組織特異性
    Expressed in intestinal cells.
  • 配列類似性
    Belongs to the GPSM family.
    Contains 4 GoLoco domains.
    Contains 9 TPR repeats.
  • ドメイン
    The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
  • 翻訳後修飾
    Phosphorylation regulates interaction with G(i/o) alpha.
  • 細胞内局在
    Cytoplasm > cytosol. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activator of G-protein signaling 3 antibody
    • AGS3 antibody
    • AGS3 homolog antibody
    • C10a antibody
    • G protein signaling modulator 1 (AGS3 like, C. elegans) antibody
    • G-protein-signaling modulator 1 antibody
    • GPSM1 antibody
    • GPSM1_HUMAN antibody
    see all

参考文献

ab111022 has not yet been referenced specifically in any publications.

レビューと Q&A

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Mouse Embryo (day 8.5))
Specification
Mouse Embryo (day 8.5)
Fixative
Paraformaldehyde
Blocking step
Serum as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 37°C
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Derek Passer

Verified customer

投稿 Oct 13 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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