製品の概要

  • 製品名Anti-GPD1L antibody
    GPD1L 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GPD1L
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 47-77 of Human GPD1L (NP_055956.1)

  • ポジティブ・コントロール
    • MCF-7 cell line lysate Mouse heart tissue lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab107509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 38 kDa.

ターゲット情報

  • 機能Play a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
  • 組織特異性Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
  • 関連疾患Defects in GPD1L are the cause of Brugada syndrome type 2 (BRS2) [MIM:611777]. BRS2 is an autosomal dominant tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
    Defects in GPD1L are a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
  • 配列類似性Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  • 細胞内局在Cytoplasm. Localized to the region of the plasma membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2210409H23Rik antibody
    • D9Ertd660e antibody
    • Glycerol 3 phosphate dehydrogenase 1 like antibody
    • Glycerol 3 phosphate dehydrogenase 1 like protein antibody
    • Glycerol-3-phosphate dehydrogenase 1-like protein antibody
    • GPD 1L antibody
    • GPD1-L antibody
    • gpd1l antibody
    • GPD1L_HUMAN antibody
    • KIAA0089 antibody
    • RGD1560123 antibody
    see all

Anti-GPD1L antibody 画像

  • Anti-GPD1L antibody (ab107509) at 1/100 dilution + MCF-7 cell line lysate at 35 µg

    Predicted band size : 38 kDa
  • Anti-GPD1L antibody (ab107509) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 38 kDa

Anti-GPD1L antibody (ab107509) 使用論文

ab107509 has not yet been referenced specifically in any publications.

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