Anti-GPCR RDC1/CXCR-7 抗体 (ab38089)
Key features and details
- Rabbit polyclonal to GPCR RDC1/CXCR-7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-GPCR RDC1/CXCR-7 antibody
GPCR RDC1/CXCR-7 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GPCR RDC1/CXCR-7 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide corresponding to Human GPCR RDC1/CXCR-7 aa 1-100 conjugated to keyhole limpet haemocyanin.
(Peptide available asab38088) -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab38089の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (2) |
1/250. Detects a band of approximately 52 kDa (predicted molecular weight: 42 kDa).Can be blocked with Human GPCR RDC1/CXCR-7 peptide (ab38088).
GPCR RCD1 is glycosylated so it is not unexpected that it runs higher than predicted (based on primary structure) in SDS PAGE. |
特記事項 |
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WB
1/250. Detects a band of approximately 52 kDa (predicted molecular weight: 42 kDa).Can be blocked with Human GPCR RDC1/CXCR-7 peptide (ab38088). GPCR RCD1 is glycosylated so it is not unexpected that it runs higher than predicted (based on primary structure) in SDS PAGE. |
ターゲット情報
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機能
Receptor for CXCL12/SDF1. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. -
組織特異性
Expressed in monocytes, basophils, and B-cells. Lower expression in CD4+ T-lymphocytes and natural killer cells. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 57007 Human
- Entrez Gene: 12778 Mouse
- Omim: 610376 Human
- SwissProt: P25106 Human
- SwissProt: P56485 Mouse
- Unigene: 471751 Human
- Unigene: 6522 Mouse
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別名
- ACKR3 antibody
- atypical chemokine receptor 3 antibody
- C X C chemokine receptor type 7 antibody
see all
画像
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All lanes : Anti-GPCR RDC1/CXCR-7 antibody (ab38089) at 1/250 dilution
Lane 1 : Human Brain Tissue Lysate
Lane 2 : Human Testis Tissue Lysate
Lane 3 : Human Liver Tissue Lysate
Lane 4 : Human Heart Tissue Lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 42 kDa
Observed band size: 52 kDa why is the actual band size different from the predicted?
GPCR RCD1 is glycosylated so it is not unexpected that it runs higher than predicted (based on primary structure) in SDS PAGE.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (25)
ab38089 は 25 報の論文で使用されています。
- Joo M et al. Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expression in vitro. Oncol Rep 47:N/A (2022). PubMed: 34958113
- Zhang J et al. SOX4 promotes the growth and metastasis of breast cancer. Cancer Cell Int 20:468 (2020). PubMed: 33005101
- Bai Y et al. RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis. Theranostics 9:3459-3475 (2019). PubMed: 31281490
- Kim N et al. CXCR7 promotes migration and invasion in head and neck squamous cell carcinoma by upregulating TGF-ß1/Smad2/3 signaling. Sci Rep 9:18100 (2019). PubMed: 31792315
- Zhang L et al. Cytokine augments the sorafenib-induced apoptosis in Huh7 liver cancer cell by inducing mitochondrial fragmentation and activating MAPK-JNK signalling pathway. Biomed Pharmacother 110:213-223 (2019). PubMed: 30476722