製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to GPCR MRGX2
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to a region from the C terminal cytoplasmic domain of Human GPCR MRGX2, conjugated to KLH.

  • ポジティブ・コントロール
    • Human spinal Cord, DRG tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab116712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
  • 組織特異性
    Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
  • 配列類似性
    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • G protein coupled receptor MRGX 2 antibody
    • G protein coupled receptor MRGX2 antibody
    • Mas related G protein coupled receptor member X2 antibody
    • Mas related gene MRGX 2 antibody
    • Mas related gene MRGX2 antibody
    • MAS related GPR member X2 antibody
    • Mas-related G-protein coupled receptor member X antibody
    • Mas-related G-protein coupled receptor member X2 antibody
    • MRGPRX 2 antibody
    • MRGPRX2 antibody
    • MRGX 2 antibody
    • MRGX2 antibody
    • MRGX2_HUMAN antibody
    see all

画像

  • Human spinal cord, DRG (formalin fixed, paraffin embedded tissue) stained with ab116712 at 20 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

プロトコール

参考文献

ab116712 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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