Anti-GPCR GPR43 抗体 (ab124272)
Key features and details
- Rabbit polyclonal to GPCR GPR43
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human, African green monkey
- Isotype: IgG
製品の概要
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製品名
Anti-GPCR GPR43 antibody
GPCR GPR43 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GPCR GPR43 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, ICC/IFmore details -
種交差性
交差種: Human, African green monkey -
免疫原
Synthetic peptide conjugated to KLH, corresponding to the C terminal region of Human GPCR GPR43.
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ポジティブ・コントロール
- Human tonsil tissue; COS7 cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine), 49% PBS
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab124272の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 5 µg/ml.
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ICC/IF |
1/100 - 1/500.
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特記事項 |
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IHC-P
Use a concentration of 5 µg/ml. |
ICC/IF
1/100 - 1/500. |
ターゲット情報
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機能
Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. -
組織特異性
Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2867 Human
- Omim: 603823 Human
- SwissProt: O15552 Human
- Unigene: 248056 Human
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別名
- Fatty acid receptor 2 antibody
- FFA2R antibody
- Ffar2 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab124272 は 3 報の論文で使用されています。
- Frei R et al. Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils. J Leukoc Biol 109:741-751 (2021). PubMed: 32803826
- Matsuya-Ogawa M et al. Oncoprotective Effects of Short-Chain Fatty Acids on Uterine Cervical Neoplasia. Nutr Cancer 71:312-319 (2019). PubMed: 30836015
- Pan P et al. Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. Carcinogenesis 38:86-93 (2017). PubMed: 27866157