Anti-GPCR G2A 抗体 (ab116586)
Key features and details
- Rabbit polyclonal to GPCR G2A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-GPCR G2A antibody
GPCR G2A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GPCR G2A -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide against the C-terminal domain of Human GPCRG2A protein (Q9UNW8) conjugated to KLH.
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ポジティブ・コントロール
- Human Spleen tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab116586の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 12 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
Use a concentration of 12 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication. -
組織特異性
Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface. - Information by UniProt
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参照データベース
- Entrez Gene: 29933 Human
- Omim: 606167 Human
- SwissProt: Q9UNW8 Human
- Unigene: 532504 Human
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別名
- G Protein Coupled Receptor G2A antibody
- G2 accumulation protein antibody
- G2A antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab116586 は 2 報の論文で使用されています。
- Klatt W et al. Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors. Sci Rep 10:15327 (2020). PubMed: 32948783
- Nassios A et al. Expression of Proton-sensing G-Protein-coupled receptors in selected skin tumors. Exp Dermatol N/A:N/A (2018). PubMed: 30339292