製品の概要

  • 製品名Anti-GnRH antibody
    GnRH 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GnRH
  • アプリケーション適用あり: ELISA, IHC-Fr, IHC-P, RIAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein (Human) conjugated to BSA.

  • ポジティブ・コントロール
    • Hypothalamus
  • 特記事項LHRH is also known as Gonadotropin-releasing hormone (GNRH).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
IHC-Fr
IHC-P
RIA
  • 追加情報This antibody is suitable for use on paraffin embedded tissues without enzymatic antigen retrieval
    Advised working dilutions are 1:50-1:100.
    Dilution buffer is 0.15 M PBS with 1% Ovalbumin and 0.09% sodium azide.
    Optimal dilution should be tested by serial dilution.
  • ターゲット情報

    • 関連性Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
    • 細胞内局在Secreted
    • 参照データベース
    • 別名
      • GnRH associated peptide 1 antibody
      • GNRH1 antibody
      • Gonadotrophin releasing hormone 1 antibody
      • GRH antibody
      • HH12 antibody
      • LHRH antibody
      • LNRH antibody
      • Luliberin I antibody
      • Luteinizing releasing hormone antibody
      • Lutenizing hormome releasing hormone antibody
      • Progonadoliberin 1 antibody
      • Progonadoliberin I antibody
      • Prolactin release inhibiting factor antibody
      see all

    Anti-GnRH antibody (ab8491) 使用論文

    ab8491 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry and your detailed protocol. We are very sorry to hear that you are having problem with this antibody. We have sold several vials of this antibody and do not have any problem with it. According to the datasheet, this pr...

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    Unfortunately the epitope is not known. We know that it recognizes several epitopes on LH-RH. In the following reference there is data about the preparation of the antigen conjugate. Van Rees, et al., 1984, Acta Endocrinologica 104: 272-278

    I have been unable to obtain a protocol for the use of this antibody in IHC from the originator. Furthermore there are no published references, so all the information we have is on the datasheet where we advise that use in IHC on PES should be without ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"