製品の概要

  • 製品名Anti-GNAT1 antibody
    GNAT1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GNAT1
  • 特異性Detects Rod Transducin alpha from bovine outer rod segments and sheep retinal extract.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Sheep, Cow, Pig
    交差が予測される動物種: Rat, Dog, Human, Xenopus laevis
  • 免疫原

    Synthetic peptide corresponding to Human Transducin alpha aa 18-31.
    Sequence:

    KLKEDAEKDARTVK


    (Peptide available as ab5002)

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 一次抗体 備考Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab3504 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 40 kDa).Can be blocked with GNAT1 peptide (ab5002).

ターゲット情報

  • 機能Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
  • 組織特異性Rod. Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium.
  • 関連疾患Night blindness, congenital stationary, autosomal dominant 3
    Night blindness, congenital stationary, 1C
  • 配列類似性Belongs to the G-alpha family. G(i/o/t/z) subfamily.
  • 発生段階Expressed at approximately postnatal day 7.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CSNBAD3 antibody
    • GBT1 antibody
    • GNAT1 antibody
    • GNAT1_HUMAN antibody
    • GNATR antibody
    • guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 1 antibody
    • guanine nucleotide binding protein G(T) alpha 1 subunit antibody
    • Guanine nucleotide-binding protein G(t) subunit alpha-1 antibody
    • Rod specific transducin antibody
    • rod-type transducin alpha subunit antibody
    • Transducin alpha-1 chain antibody
    • transducin, rod-specific antibody
    see all

Anti-GNAT1 antibody 画像



  • Predicted band size : 40 kDa

    Western blot detection of Trabsducin alpha on sheep retinal extracts using ab3504.

Anti-GNAT1 antibody (ab3504) 使用論文

ab3504 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"