Anti-GNAL 抗体 (ab74049)
Key features and details
- Rabbit polyclonal to GNAL
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-GNAL antibody -
製品の詳細
Rabbit polyclonal to GNAL -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human GNAL aa 60-90 (internal sequence).
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ポジティブ・コントロール
- Human brain tissue. Extracts from LOVO cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab74049の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 44 kDa.
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IHC-P |
1/50 - 1/100.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 44 kDa. |
IHC-P
1/50 - 1/100. |
ターゲット情報
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機能
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. -
組織特異性
Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined. -
配列類似性
Belongs to the G-alpha family. G(s) subfamily. - Information by UniProt
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参照データベース
- Entrez Gene: 2774 Human
- Entrez Gene: 14680 Mouse
- Entrez Gene: 24611 Rat
- Omim: 139312 Human
- SwissProt: P38405 Human
- SwissProt: Q8CGK7 Mouse
- SwissProt: P38406 Rat
- Unigene: 136295 Human
see all -
別名
- Adenylate cyclase stimulating G alpha protein, olfactory type antibody
- Adenylate cyclase-stimulating G alpha protein antibody
- DYT25 antibody
see all
画像
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All lanes : Anti-GNAL antibody (ab74049) at 1/500 dilution
Lane 1 : extracts from LOVO cells
Lane 2 : extracts from LOVO cells with immunizing peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 44 kDa
Observed band size: 44 kDa -
Immunohistochemistry analysis of paraffin-embedded human brain tissue using 1/50 ab74049, in the absence (left) or presence (right) of the immunizing peptide.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab74049 は 4 報の論文で使用されています。
- Song H et al. Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury. J Proteome Res 17:858-869 (2018). PubMed: 29215295
- Gonçalves I et al. 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus. FEBS J 283:1748-66 (2016). PubMed: 26934374
- Zhang L et al. Dopamine receptor and Ga(olf) expression in DYT1 dystonia mouse models during postnatal development. PLoS One 10:e0123104 (2015). WB . PubMed: 25860259
- Griffin CA et al. MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Dev Cell 17:649-61 (2009). WB ; Mouse . PubMed: 19922870