製品の概要

  • 製品名Anti-GM2A antibody
    GM2A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GM2A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 32-62 of Human GM2A (NP_000396.2).

  • ポジティブ・コントロール
    • A2058 cell lysate, Mouse liver tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab107501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 21 kDa.

ターゲット情報

  • 機能Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • 関連疾患Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • 翻訳後修飾The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • 細胞内局在Lysosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cerebroside sulfate activator protein antibody
    • ganglioside GM2 activator antibody
    • Ganglioside GM2 activator isoform short antibody
    • Ganglioside GM2 activator precursor antibody
    • GM2 activator antibody
    • GM2 AP antibody
    • GM2 ganglioside activator antibody
    • GM2 ganglioside activator protein antibody
    • GM2-AP antibody
    • GM2A antibody
    • GM2AP antibody
    • OTTHUMP00000160619 antibody
    • SAP 3 antibody
    • SAP-3 antibody
    • SAP3 antibody
    • SAP3_HUMAN antibody
    • Shingolipid activator protein 3 antibody
    • Sphingolipid activator protein 3 antibody
    see all

Anti-GM2A antibody 画像

  • Anti-GM2A antibody (ab107501) at 1/100 dilution + A2058 cell lysate at 35 µg

    Predicted band size : 21 kDa
  • Anti-GM2A antibody (ab107501) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 21 kDa

Anti-GM2A antibody (ab107501) 使用論文

ab107501 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab107501.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"