製品の概要

  • 製品名
    GM 6001
  • 製品の詳細
    Broad spectrum MMP inhibitor
  • 別名
    • Galardin
    • ilomastat
  • 生理活性の詳細

    Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

  • 精製度
    > 98%

製品の特性

  • 体系名
    (2R)-N4-Hydroxy-N1-[(1S)-2-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
  • 分子量
    388.47
  • 構造式
    Chemical Structure
  • 分子式
    C20H28N4O4
  • CAS 番号
    142880-36-2
  • PubChem 登録番号
    132519
  • 保存方法
    Store at +4°C. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    ONC(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cnc1ccccc12)C(=O)NC
  • 由来

    Synthetic

    GM 6001 (ab120845) 使用論文

    This product has been referenced in:
    • Zhang H  et al. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics 8:206-20 (2011). Read more (PubMed: 21455784) »
    • Levy DE  et al. Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998). Read more (PubMed: 9457244) »
    • Grobelny D  et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31:7152-4 (1992). Read more (PubMed: 1322694) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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