製品の概要

  • 製品名Anti-Glypican 6 antibody
    Glypican 6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Glypican 6
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide selected from the N terminal region of human Glypican 6, conjugated to KLH

  • ポジティブ・コントロール
    • K562 cell line lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Ammonium Sulphate Precipitation
  • 特記事項(精製)ab71343 is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab71343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).

ターゲット情報

  • 機能Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.
  • 組織特異性Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).
  • 関連疾患Defects in GPC6 are a cause of omodysplasia type 1 (OMOD1) [MIM:258315]. OMOD1 is a rare autosomal recessive skeletal dysplasia characterized by severe congenital micromelia with shortening and distal tapering of the humeri and femora to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin. Note=Point mutations leading to protein truncation, as well as larger genomic rearrangements resulting in exon deletions, have been found in family segregating omodysplasia type 1. All mutations identified in individuals affected by omodysplasia could lead to the absence of a functional protein, the mutant RNAs being suspected to be nonsense-mediated mRNA decay (NMD) targets. Even if the mRNA escapes NMD and is translated, all mutations are expected to disrupt the three-dimensional protein structure and often to abolish multiple highly conserved cysteine residues.
  • 配列類似性Belongs to the glypican family.
  • 細胞内局在Cell membrane and Secreted > extracellular space.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GPC 6 antibody
    • Glypican 6 [Precursor] antibody
    • Glypican proteoglycan 6 antibody
    • Gpc6 antibody
    • GPC6_HUMAN antibody
    • MGC126288 antibody
    • OMIMD1 antibody
    • PRO705 antibody
    • Secreted glypican 6 antibody
    • Secreted glypican-6 antibody
    • UNQ369 antibody
    see all

Anti-Glypican 6 antibody 画像

  • Anti-Glypican 6 antibody (ab71343) at 1/60 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 63 kDa
    Observed band size : 63 kDa

Anti-Glypican 6 antibody (ab71343) 使用論文

ab71343 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71343.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"