保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
バッファー0.02M K Phosphate, 0.15M NaCl, 0.01% Sodium Azide, pH7.2
特記事項（精製）This product was prepared from monospecific antiserum by a delipidation and defibrination. Assay by immunoelectrophoresis resulted in a single precipitin arc against purified and partially purified Glutamine Synthetase [Microbial].
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報immunoblotting (western or dot blot), ELISA (1:10,000 to 1:40,000), immunoprecipitation and most immunological methods requiring high titer and specificity.
機能This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
関連疾患Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
Ivanovska N & Dimitrova P Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine. Arthritis Res Ther13:R44 (2011).
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Yuan J et al. Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol Syst Biol5:302 (2009).
Read more (PubMed: 19690571) »