Anti-Glutamine Synthetase 抗体 [6/Glutamine Synthetase] (ab125724)
Key features and details
- Mouse monoclonal [6/Glutamine Synthetase] to Glutamine Synthetase
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase]
Glutamine Synthetase 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [6/Glutamine Synthetase] to Glutamine Synthetase -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Sheep -
免疫原
Full length protein, corresponding to amino acids 1-373 of Sheep Glutamine Synthetase.
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ポジティブ・コントロール
- Human liver tissue; Human Hepatocellular carcinoma tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide
Buffer with protein carrier and preservative. -
Concentration information loading...
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特記事項(精製)
Purity >90% by SDS-PAGE. -
ポリ/モノ
モノクローナル -
クローン名
6/Glutamine Synthetase -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab125724の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/150 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/150 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
ターゲット情報
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機能
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. -
関連疾患
Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. -
配列類似性
Belongs to the glutamine synthetase family. -
発生段階
Expressed during early fetal stages. -
細胞内局在
Cytoplasm. Mitochondrion. - Information by UniProt
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参照データベース
- Entrez Gene: 2752 Human
- Omim: 138290 Human
- SwissProt: P15104 Human
- Unigene: 518525 Human
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別名
- cell proliferation-inducing protein 59 antibody
- Cgl2214 antibody
- GLNA antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab125724 は 5 報の論文で使用されています。
- Todd L et al. Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina. Stem Cells 36:392-405 (2018). PubMed: 29193451
- Todd L et al. BMP- and TGFß-signaling regulate the formation of Müller glia-derived progenitor cells in the avian retina. Glia 65:1640-1655 (2017). PubMed: 28703293
- Todd L et al. Comparative analysis of glucagonergic cells, glia, and the circumferential marginal zone in the reptilian retina. J Comp Neurol 524:74-89 (2016). PubMed: 26053997
- Todd L et al. Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina. Sci Rep 6:35703 (2016). PubMed: 27759082
- Todd L et al. Heparin-binding EGF-like growth factor (HB-EGF) stimulates the proliferation of Müller glia-derived progenitor cells in avian and murine retinas. Mol Cell Neurosci 69:54-64 (2015). PubMed: 26500021