Anti-Glucocorticoid Receptor 抗体 [8E9] (ab11379)

製品の概要

  • 製品名Anti-Glucocorticoid Receptor antibody [8E9]
    Glucocorticoid Receptor 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [8E9] to Glucocorticoid Receptor
  • 特異性Ab11379 recognises the human glucocorticoid receptor.
  • アプリケーション適用あり: WB, ELISAmore details
    適用なし: IHC-Fr,IHC-P or IHC-R
  • 種交差性
    交差種: Human
  • 免疫原

    26 amino acid peptide corresponding to residues 150-176 of human GCR linked to thyroglobulin (human).

  • エピトープClone 8E9 binds to an epitope between amino acids 167-176.
  • 特記事項This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 87 kDa.
ELISA 1/1000.
  • 追加情報Is unsuitable for IHC-Fr,IHC-P or IHC-R.
  • ターゲット情報

    • 機能Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
    • 組織特異性Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
    • 関連疾患Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.
    • 配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • 翻訳後修飾Increased proteasome-mediated degradation in response to glucocorticoids.
      Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211.
      Sumoylated; this reduces transcription transactivation.
      Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
    • 細胞内局在Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • GCCR antibody
      • GCR antibody
      • GCR_HUMAN antibody
      • GCRST antibody
      • glucocorticoid nuclear receptor variant 1 antibody
      • Glucocorticoid receptor antibody
      • GR antibody
      • GRL antibody
      • Grl1 antibody
      • nr3c1 antibody
      • Nuclear receptor subfamily 3 group C member 1 antibody
      • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antibody
      see all

    Anti-Glucocorticoid Receptor antibody [8E9] (ab11379) 使用論文

    ab11379 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab11379.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"