製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to GLRB
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 102-132 of Human GLRB (NP_001159532.1, NP_000815.1).

  • ポジティブ・コントロール
    • Mouse cerebellum tissue lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 56 kDa.

ターゲット情報

  • 関連性
    GLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior.
  • 細胞内局在
    Plasma membrane; multi-pass membrane protein.
  • 参照データベース
  • 別名
    • Glycine receptor 58 kDa subunit antibody
    • Glycine receptor beta antibody
    • Glycine receptor subunit beta antibody
    • Glycine receptor, beta subunit antibody
    • OTTHUMP00000220896 antibody
    • OTTHUMP00000220897 antibody
    see all

画像

  • Anti-GLRB antibody (ab123886) at 1/100 dilution + Mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 56 kDa

プロトコール

参考文献

This product has been referenced in:
  • James VM  et al. Novel missense mutations in the glycine receptor ß subunit gene (GLRB) in startle disease. Neurobiol Dis 52:137-49 (2013). WB ; Human . Read more (PubMed: 23238346) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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