製品の概要

  • 製品名Anti-GliS2 antibody
    GliS2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GliS2
  • 特異性ab28462 recognises GLIS2.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide derived from residues 183 - 232 of human GliS2.

    .

  • ポジティブ・コントロール
    • HepG2 cell lysates

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab28462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/312500.

ターゲット情報

  • 機能Can act either as a transcription repressor or as a transcription activator, depending on the cell context. Represses the transcriptional activation mediated by CTNNB1 in the Wnt pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
  • 組織特異性Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
  • 関連疾患Defects in GLIS2 are the cause of nephronophthisis type 7 (NPHP7) [MIM:611498]. NPHP7 is an autosomal recessive disorder resulting in end-stage renal disease during childhood or adolescence. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
  • 配列類似性Belongs to the GLI C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • ドメインThe C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding.
  • 翻訳後修飾C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase.
  • 細胞内局在Nucleus speckle. Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ38247 antibody
    • GLI similar 2 antibody
    • GLI-similar 2 antibody
    • GLIS 2 antibody
    • GLIS family zinc finger 2 antibody
    • glis2 antibody
    • GLIS2_HUMAN antibody
    • Kruppel like zinc finger protein GLIS2 antibody
    • Neuronal Krueppel-like protein antibody
    • Zinc finger protein GLIS2 antibody
    see all

Anti-GliS2 antibody 画像

  • Anti-GliS2 antibody (ab28462) at 0.5 µg/ml

    Predicted band size : 56 kDa
    Observed band size : 56 kDa

Anti-GliS2 antibody (ab28462) 使用論文

ab28462 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. The difference between ab48861 and ab28462 can be found in the purity and concentration. I have listed the differences below and some references that might be useful to you. ab48861 purity: protein A purified concent...

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