製品の概要

  • 製品名Anti-Glicentin antibody
    Glicentin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Glicentin
  • 特異性This glicentin antibody is reactive with glucagon as well as glicentin. Glicentin contains the glucagon sequence and is produced in endocrine cells of the distal intestine, in pancreatic glucagon cells and in nerves in the brain.
  • アプリケーション適用あり: WB, IHC-P, IHC-Fr, Dot blotmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Porcine pancreatic Glucagon/BSA

  • ポジティブ・コントロール
    • Pancreas and small intestine

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8493 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
IHC-Fr
Dot blot
  • 追加情報This antibody can be used for the diagnosis of tumours from the distal intestin (rectal carcinoids) as well as pancreatic islet cell tumours.
    This antibody is suitable for paraffin embedded tissues without enzymatic antigen retrieval.
    Advised working dilution is 1:50.
    Dilution buffer is 0.15 M PBS with 1.0% Ovalbumin and 0.1% sodium azide.
    Optimal dilution should be tested by serial dilution.
  • ターゲット情報

    • 機能Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
      GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell apoptosis.
      GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.
      Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
      Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
    • 組織特異性Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
    • 配列類似性Belongs to the glucagon family.
    • 翻訳後修飾Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 製品の状態Cleaved into the following 8 chains: 1.Glicentin; 2.Glicentin-related polypeptide = GRPP; 3.Oxyntomodulin = OXM = OXY; 4.Glucagon; 5.Glucagon-like peptide 1 = GLP-1; 6.Glucagon-like peptide 1(7-37) = GLP-1(7-37); 7.Glucagon-like peptide 1(7-36) = GLP-1(7-36); 8.Glucagon-like peptide 2 = GLP-2.
    • 別名
      • GCG antibody
      • glicentin-related polypeptide antibody
      • GLP-1 antibody
      • GLP-1(7-36) antibody
      • GLP-1(7-37) antibody
      • GLP-2 antibody
      • GLUC_HUMAN antibody
      • Glucagon antibody
      • glucagon-like peptide 1 antibody
      • Glucagon-like peptide 2 antibody
      • GRPP antibody
      • OXM antibody
      • OXY antibody
      see all

    Anti-Glicentin antibody (ab8493) 使用論文

    ab8493 has not yet been referenced specifically in any publications.

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