製品の概要

  • 製品名Anti-GJB3 antibody
    GJB3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GJB3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Zebrafish
  • 免疫原

    Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 (

    MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKD

    ) of Mouse GJB3 (NP_032152.1).

  • ポジティブ・コントロール
    • SP2/0 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab108285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.125 µg/ml. Predicted molecular weight: 31 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 関連疾患Defects in GJB3 are a cause of erythrokeratodermia variabilis (EKV) [MIM:133200]. EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
    Defects in GJB3 are the cause of deafness autosomal dominant type 2B (DFNA2B) [MIM:612644]. DFNA2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • 配列類似性Belongs to the connexin family. Beta-type (group I) subfamily.
  • 細胞内局在Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Connexin 31 antibody
    • Connexin-31 antibody
    • Connexin31 antibody
    • CX 31 antibody
    • Cx31 antibody
    • CXB3_HUMAN antibody
    • DFNA 2 antibody
    • DFNA2 antibody
    • DFNA2B antibody
    • EKV antibody
    • FLJ22486 antibody
    • Gap junction beta 3 protein antibody
    • Gap junction beta-3 protein antibody
    • Gap junction protein beta 3 31kDa antibody
    • Gap junction protein beta 3 antibody
    • GJB 3 antibody
    • Gjb3 antibody
    • MGC102938 antibody
    see all

Anti-GJB3 antibody 画像

  • Anti-GJB3 antibody (ab108285) at 0.125 µg/ml + SP2/0 cell lysate at 10 µg

    Predicted band size : 31 kDa

Anti-GJB3 antibody (ab108285) 使用論文

ab108285 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (E14.5 wildtype gut)
Specification E14.5 wildtype gut
Fixative Formaldehyde
Permeabilization Yes - 0.1% Triton X-100
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C
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投稿 Jul 19 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"