製品の概要

  • 製品名Anti-GJA8 antibody
    GJA8 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GJA8
  • アプリケーション適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH: 10-30 amino acids in length from the C terminus of GJA8.

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100.
ELISA 1/1000.

ターゲット情報

  • 機能One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 組織特異性Eye lens.
  • 関連疾患Defects in GJA8 are the cause of cataract zonular pulverulent type 1 (CZP1) [MIM:116200]. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
    Defects in GJA8 are the cause of cataract-microcornea syndrome (CAMIS) [MIM:116150]. Cataract-microcornea syndrome is characterized by the association of congenital cataract and microcornea without any other systemic anomaly or dysmorphism. Clinical findings include a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye, and an inherited cataract, which is most often bilateral posterior polar with opacification in the lens periphery. The cataract progresses to form a total cataract after visual maturity has been achieved, requiring cataract extraction in the first to third decade of life. Microcornea-cataract syndrome can be associated with other rare ocular manifestations, including myopia, iris coloboma, sclerocornea and Peters anomaly. Transmission is in most cases autosomal dominant, but cases of autosomal recessive transmission have recently been described.
  • 配列類似性Belongs to the connexin family. Alpha-type (group II) subfamily.
  • 細胞内局在Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAE antibody
    • CAE1 antibody
    • cataract, zonular pulverulent 1 (FY-linked) antibody
    • Connexin 50 antibody
    • Connexin-50 antibody
    • Cx50 antibody
    • CXA8_HUMAN antibody
    • Gap junction alpha 8 protein antibody
    • Gap junction alpha-8 protein antibody
    • Gap junction membrane channel protein alpha 8 (connexin 50) antibody
    • gap junction protein, alpha 8, 50kD antibody
    • Gja8 antibody
    • Lens fiber protein MP70 antibody
    see all

Anti-GJA8 antibody 画像

  • Formalin-fixed and paraffin-embedded human breast carcinoma tissue labelled with ab59928 at 1/50 dilution followed by peroxidase-conjugation to the secondary antibody and AEC staining.

Anti-GJA8 antibody (ab59928) 使用論文

ab59928 has not yet been referenced specifically in any publications.

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