Anti-GIP 抗体 [04] (ab30679)
Key features and details
- Mouse monoclonal [04] to GIP
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-GIP antibody [04]
GIP 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [04] to GIP -
由来種
Mouse -
特異性
Ab30679 recognises GIP. It cross reacts up to 10% with PACAP and GLP2 but <0.1% with glucagon, GLP1 or VIP. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic human GIP coupled to carrier. The immunogen was adsorbed onto Al(OH)3 and emulsified in Freund's incomplete adjuvant.
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特記事項
Fusion partner: SP2/mIL6.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 0.87% Sodium chloride -
Concentration information loading...
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精製度
Protein A purified -
一次抗体 備考
Fusion partner: SP2/mIL6. -
ポリ/モノ
モノクローナル -
クローン名
04 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab30679の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (1) |
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. -
配列類似性
Belongs to the glucagon family. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 2695 Human
- Omim: 137240 Human
- SwissProt: P09681 Human
- Unigene: 1454 Human
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別名
- Gastric Inhibitory Peptide antibody
- Gastric inhibitory polypeptide antibody
- Gastric inhibitory polypeptide precursor antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab30679 は 8 報の論文で使用されています。
- Yan S et al. Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion. Cell Rep 38:110179 (2022). PubMed: 34986353
- Chu L et al. In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. Cell Chem Biol 29:1368-1380.e5 (2022). PubMed: 35998625
- McKimpson WM et al. FOXO1 Is Present in Stomach Epithelium and Determines Gastric Cell Distribution. Gastro Hep Adv 1:733-745 (2022). PubMed: 36117550
- Vazquez SE et al. Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. Elife 9:N/A (2020). PubMed: 32410729
- Palha AM et al. Differential GIP/GLP-1 intestinal cell distribution in diabetics' yields distinctive rearrangements depending on Roux-en-Y biliopancreatic limb length. J Cell Biochem 119:7506-7514 (2018). PubMed: 29761876
- Lim DM et al. Difference in protective effects of GIP and GLP-1 on endothelial cells according to cyclic adenosine monophosphate response. Exp Ther Med 13:2558-2564 (2017). PubMed: 28565879
- Deane AM et al. The effects of critical illness on intestinal glucose sensing, transporters, and absorption. Crit Care Med 42:57-65 (2014). PubMed: 23963126
- Young RL et al. Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes 62:3532-41 (2013). Human . PubMed: 23761104