製品の概要

  • 製品名Anti-Ghrelin antibody [45]
    Ghrelin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [45] to Ghrelin
  • 特異性ab112477 binds Human ghrelin and Human des-acyl ghrelin, cross-reacting ~5% with rat ghrelin (determined by sandwich ELISA).
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic Human Ser3-octanoyl ghrelin-28

  • エピトープNot determined. Probably includes residues 11 or 12 to account for the lower cross-reactivity with rat ghrelin.

製品の特性

ターゲット情報

  • 機能Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • 組織特異性Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • 配列類似性Belongs to the motilin family.
  • 翻訳後修飾O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Appetite regulating hormone antibody
    • Ghrelin 27 antibody
    • Ghrelin 28 antibody
    • Ghrelin and obestatin prepropeptide antibody
    • Ghrelin antibody
    • Ghrelin/obestatin prepropeptide antibody
    • ghrl antibody
    • GHRL_HUMAN antibody
    • Growth hormone releasing peptide antibody
    • Growth hormone secretagogue antibody
    • Growth hormone-releasing peptide antibody
    • M46 protein antibody
    • Motilin related peptide antibody
    • Motilin-related peptide antibody
    • MTLRP antibody
    • Obestatin antibody
    • Protein M46 antibody
    see all

Anti-Ghrelin antibody [45] (ab112477) 使用論文

This product has been referenced in:

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