製品の概要

  • 製品名Anti-GGT1 antibody
    GGT1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GGT1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Pig
  • 免疫原

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-196 of Human GGT1 (NP_005256).

  • ポジティブ・コントロール
    • MOLT4 whole cell lysate; 293T, A431, H1299, HeLaS3, HepG2 and Raji cell lysates

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 61 kDa.

ターゲット情報

  • 機能Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.
  • 組織特異性Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
  • パスウェイSulfur metabolism; glutathione metabolism.
  • 関連疾患Defects in GGT1 are a cause of glutathionuria (GLUTH) [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.
  • 配列類似性Belongs to the gamma-glutamyltransferase family.
  • 翻訳後修飾N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD224 antibody
    • D22S672 antibody
    • D22S732 antibody
    • Gamma glutamyl transpeptidase antibody
    • Gamma glutamyltransferase 1 antibody
    • Gamma glutamyltranspeptidase 1 antibody
    • Gamma-glutamyltransferase 1 antibody
    • Gamma-glutamyltranspeptidase 1 light chain antibody
    • GGT 1 antibody
    • GGT antibody
    • GGT1 antibody
    • GGT1_HUMAN antibody
    • Glutamyl transpeptidase antibody
    • Glutathione hydrolase 1 antibody
    • GTG antibody
    • Leukotriene C4 hydrolase antibody
    • MGC96892 antibody
    • MGC96904 antibody
    • MGC96963 antibody
    • OTTHUMP00000028921 antibody
    • OTTHUMP00000197959 antibody
    see all

Anti-GGT1 antibody 画像

  • Anti-GGT1 antibody (ab96466) at 1/500 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 61 kDa

Anti-GGT1 antibody (ab96466) 使用論文

ab96466 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab96466.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"